Top Companies in Bone Graft Substitutes Market | In-depth Research Report Offering Key Insights, Statistics, Future Scope, Emerging Opportunities | Vantage Market Research

Bone Graft Substitutes are biologics used as an alternative to autologous bone grafts i.e., obtained from the same individual.

Top Companies in Bone Graft Substitutes Market | In-depth Research Report Offering Key Insights, Statistics, Future Scope, Emerging Opportunities | Vantage Market Research
bone graft substitutes market

Market Overview:

The Global Bone Graft Substitutes Market was valued at USD 2.7 Billion in the year 2021 and is anticipated to reach a value of USD 3.8 Billion by the year 2028. The Global Market is forecasted to grow to exhibit a Compound Annual Growth Rate (CAGR) of 5.9% over the forecast period. Bone Grafts are implantable materials that promote bone formation, healing, and skeletal reconstruction because of their osteogenic, osteoconductive, and osteoinductive properties. They are utilized in sports, trauma, plastic, facial, and spinal surgeries. In addition, they are used to fill voids in case of the absence of bones or help provide structural stability. Bone grafting is the surgical procedure for replacing a missing or defective bone with a material (bone graft) from a patient's body, cadaver, animal, or a different person. It uses in wound healing, complex fracture treatment, and others. In addition, bone grafts are widely adopted for orthopedic surgeries.

Furthermore, the expansion of the Global Bone Grafts Substitutes Market is fuelled by various factors such as the increasing incidence of musculoskeletal disorders, the growth of biocompatible synthetic bone grafts, and advancements in the medical field. On the other hand, high costs of surgeries and ethical issues for bone grafting procedures might limit the bone grafts and substitute market growth. On the contrary, an increase in focus of key players toward R&D activities in bone grafts & their substitutes and an upsurge in demand for orthopedic procedures among the senior population will likely offer many opportunities for the key players in the future.

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Some of the key players operating in the Bone Graft Substitutes Market are listed below:

Company Name

Revenue in the US

  • AlloSource

$135 Million

  • Baxter International Inc

$12 Billion

  • DePuy Synthes, Inc

<$5 Million

  • Medtronic, Inc.

$31 Billion

  • NuVasive Inc.

$1 Billion

  • Orthofix Holdings Inc.

$457 Million

  • Smith & Nephew Inc.

$5 Billion


  1. Allo Source

Founded in 1994, AlloSource provides health and allied services. The company offers live mesenchymal stem cell transplants & stem cell tissue for surgeries, progressive bone and tissue-based medical products, and skin allografts for victims suffering from traumatic burn injuries. The company has one of the country's largest tissue networks, making over 200 types of clear skin, bone, and soft-tissue allografts for use in an array of life-saving and life-enhancing medical procedures.

  1. Baxter International

Founded in 1994, Baxter International Inc. is headquartered in the United States. The company develops, manufactures, and markets products and technologies related to hemophilia, immune disorders, kidney disease, infectious diseases, and trauma, other chronic and acute medical conditions. The company's products are used by hospitals, rehabilitation centers, kidney dialysis centers, nursing homes, doctors' offices, and research laboratories.

  1. DePuy Synthes Inc.

DePuy Synthes, Inc. manufactures and distributes orthopedic devices. In addition, the company offers a knee system, air pen drive, reverse shoulder system, and power tools. The company has around 10 thousand working employees. The company serves customers in the United States.

  1. Medtronic, Inc.

Medtronic, Inc. provides medical devices. Medtronic, Inc. offers surgical devices, apparatus, respiratory monitoring systems, medical supplies, medical instruments, and other equipment. The company serves patients and health care professionals worldwide. The company was founded it was founded in 1949.

  1. Nuvasive Inc.

NuVasive Inc. was founded in 1997 and is headquartered in the United States. The company is a medical device company focused on minimally invasive surgical products and integrated solutions for spine surgery. The company's spine surgery products contribute the majority of revenue. NuVasive Inc's key offering is the maximum access surgery minimally disruptive surgical platform that minimizes soft-tissue disruption and contact with critical nerves & maximizes visualization during spine fusion surgery. The company also develops biologics to aid spinal fusion or bone-healing processes like a collagen-based synthetic bone substitute & synthetic bone-graft material.

  1. Orthofix Holdings Inc.

The company was established in 1980 and is located in the United States. The company has two strategic business units - Orthofix Spine and Orthofix Orthopedics - with more than 1,000 employees developing, manufacturing, and distributing our diverse product lines in more than 60 countries worldwide. In addition, the company operates as a holding company. The company, through its subsidiaries, manufactures, develops, and distributes orthopedic and spine products.

  1. Smith & Nephew Inc.

Smith & Nephew Inc. was founded in 1980 and is headquartered in the United States. The company designs, manufacture, and markets orthopedic devices, wound-care solutions, sports medicine, and arthroscopic technologies. Around 42% of the U.K.-based firm's revenue comes from orthopedic products, and another 30% is from sports medicine and ENT. The remaining 28% of income is from the advanced wound therapy segment. Roughly half of Smith & Nephew's total revenue comes from the US. Just over 30% is from other developed markets, and emerging markets account for the remainder.

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