Lipid Nanodiscs Market Size to Reach $1.7 Billion at a CAGR of 7.7% by 2028

The Global Lipid Nanodiscs Market is valued at USD 1.1 Billion in 2021 and is projected to reach a value of USD 1.7 Billion by 2028 at a CAGR of 7.7% over the forecast period.

Lipid nanodiscs are a type of nanoscale lipid bilayer particles that are increasingly being used in biophysical and biochemical research for studying the structure and function of membrane proteins. Lipid nanodiscs consist of a circular patch of lipid bilayer surrounded by a belt of amphipathic proteins. These nanodiscs offer several advantages over traditional methods for studying membrane proteins, including increased stability, solubility, and flexibility.

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While the lipid nanodisc market is currently small, it is expected to grow as research into membrane proteins and drug delivery systems continues to expand. The demand for lipid nanodiscs is driven by the need for more effective drug delivery methods, especially for hydrophobic drugs that are difficult to administer.

Top Companies in Lipid Nanodiscs Market

• Merck KGaA (Germany)
• ideXLab (Paris)
• Cube Biotech (Germany)
• Anatrace Products
• MEMPRO USA LTD (U.S.)
• Nano Temper (U.S.)

Lipid Nanodiscs Market Dynamics:

Large organic molecules are known as lipids, often characterized as derivates of fatty acids or similarly related substances. Lipid Nanodiscs Market are often soluble in alcohols and organic solvents but not water. The primary drivers for the global Lipid Nanodiscs Market are their appeal as a valuable tool for various biochemical and molecular model systems for membrane proteins. Rising consumer demand for lipids as a nutritional supplement, increasing consumer knowledge, and changing eating patterns will increase market footprint. Also, Lipid Nanodiscs Market greatly impact how chronic conditions like diabetes, cancer, cystic fibrosis, asthma, and arthritis are treated.

Increased development in the research and development department by prominent market leaders is expected to increase the footprint of the global Lipid Nanodiscs Market during the forecast period. Lipid Nanodiscs Market led to developing a native-like membrane-based environment, making it easier to prepare biologically active folded forms of integral membrane proteins. Consumers in developed economies are becoming more aware of the health benefits of Lipid Nanodiscs Market. These proteins are required for structural research and examination of membrane proteins, which will fuel the growth of the Lipid Nanodiscs Market during the forecast period.

Studies have indicated a rising availability of products among the most common distribution channels. Additionally, increasing R&D activities in the Lipid Nanodiscs Market and emerging production strategies in drug development activities, including cancer vaccines, will further widen the scope of the global Lipid Nanodiscs Market during the forecast period. Emerging economies such as covalently circularized nanodiscs (cND) and DNA corralled nanodiscs (DCND) are major products contributing to substantial market growth. Additionally, the inclusion of isolation, purification, and solubilization-based applications for various preparative and analytical procedures will enable an increased footprint of the global Lipid Nanodiscs Market during the forecast period.

Nanodiscs are required for the solubility of membrane proteins for imitating the amphipathic environment of a lipid bilayer while keeping the membrane protein structure in a physiologically appropriate form. This is expected to fuel the market growth during the forecast period. However, there are numerous substitute goods in the market and decreased penetration within the global population is expected to hinder the growth of the global Lipid Nanodiscs Market during the forecast period. Also, the inability to treat patients with certain medical disorders, the maturity of raw material suppliers, decreasing sustainability of fishing practices, and lowered catching limits will further cause hindrances to the growth of the global Lipid Nanodiscs Market during the forecast period.

Overview of Lipid Nanodiscs

Lipid nanodiscs are a type of nanoscale particle that is composed of a patch of lipid bilayer surrounded by a belt of amphipathic proteins, typically membrane scaffold proteins. They are used in biophysical and biochemical research for studying the structure and function of membrane proteins, and for stabilizing and solubilizing membrane proteins for biochemical and biophysical assays.

Lipid nanodiscs have several advantages over traditional methods for studying membrane proteins. They provide a native-like environment for the membrane protein, allowing for more accurate and reliable data to be collected. They are also highly flexible and customizable, allowing researchers to tailor the composition of the nanodisc to suit their specific needs. 

In addition to their use in research, lipid nanodiscs have potential applications in drug delivery and therapeutics. Their biocompatibility, stability, and ability to encapsulate hydrophobic drugs make them attractive candidates for drug delivery systems. However, further research is needed to fully explore their potential in this area.

The market for lipid nanodiscs is currently small but expected to grow as research into membrane proteins and drug delivery systems continues to expand. The demand for lipid nanodiscs is driven by the need for more effective drug delivery methods, especially for hydrophobic drugs that are difficult to administer. The market is primarily divided into research and development and drug delivery, with North America currently dominating the market.

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Lipid Nanodiscs Challenges

• Complexity of preparation: The preparation of lipid nanodiscs is a complex process that requires specialized expertise and equipment. The process involves assembling multiple components, including lipids, membrane scaffold proteins, and detergents, which must be carefully optimized to ensure the desired properties of the nanodiscs.
• Batch-to-batch variability: Due to the complexity of the preparation process, there is a risk of batch-to-batch variability in the properties of the lipid nanodiscs. This can make it difficult to reproduce results and limit the nanodiscs' utility for certain applications.
• Limited scalability: The production of lipid nanodiscs is currently limited to small-scale batches, which can be a barrier to their widespread use. Developing methods for large-scale production and purification of lipid nanodiscs is an ongoing challenge.
• Biocompatibility and toxicity concerns: Although lipid nanodiscs are generally considered biocompatible, there are still concerns about their potential toxicity and immunogenicity. Further research is needed to fully understand the safety profile of lipid nanodiscs and to develop methods for minimizing any potential adverse effects.
• Cost: The preparation of lipid nanodiscs can be expensive, which can limit their use in certain applications. Developing more cost-effective methods for producing lipid nanodiscs is an important area of ongoing research.

Key Developments:

• February 2022: Merck announced that they completed the purchase of Exelead for approximately USD 780 million in cash. At the same time, this purchase is subject to regulatory approvals and other usual closing conditions. This purchase will integrate within Merck's Life Science Division by providing their client with comprehensive contract development and manufacturing organization (CDMO) services spanning the whole mRNA supply chain. Merck is expected to increase sales by more than €500 million through this acquisition to scale up to Exelead's technology.
• March 2022: NanoTemper Technologies announced the availability of Spectral Shift technology within their Dianthus instrument. This instrument is designed to tackle the most difficult affinity-based screening in various drug developments. This ground-breaking method is expected to help scientists to cope with extremely complicated molecular interactions under the current challenging medication and therapeutic targets, including fragment libraries, intrinsically disordered proteins (IDPs), and proteolysis-targeting chimeras.

Lipid Nanodiscs Market Regional Analysis

The Lipid Nanodiscs Market in North America is expected to register the largest market share in revenue during the forecast period. Factors include increasing activities within research & development activities, numerous biotechnology start-ups solving issues related to nanodisc platforms, and an increasing number of major pharmaceutical companies in the region. Additionally, the rising utilization of Lipid Nanodiscs Market within major pharmaceutical corporations will fuel market growth. The presence of various research organizations in the region, increasing partnerships of major pharmaceutical companies, an increasing number of studies based on nanodisc technology & rising number of government-based research projects will lead to an expanded Lipid Nanodiscs Market in North America.

Europe is expected to grow with the fastest-growing CAGR during the forecast period due to increasing government funding for various research & development activities. Additionally, there is an increasing number of research studies and government-funded research projects, such as the Horizon-2020 initiatives by the European Commission. These factors will lead to sustainable growth in the European region.

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